Kar Karyotype and Car Carcinogen

While reading a Quora Article (see image below), one of the answers given to the proposed question involved the world “Karyotype”.  A word that jives with my previous post made yesterday, Bar Car Kar, note the following info from the post: 

• Carmen Karr (16 March 1865 – 29 December 1943) 

So we now have a “Names/Words Beginning with Kar” pattern cluster in the works.   This is a prompt to investigate the  Karyotype Wikipedia page, note from the article:

Chromosomes were first observed in plant cells by Carl Wilhelm von Nägeli in 1842. Their behavior in animal (salamander) cells was described by Walther Flemming, the discoverer of mitosis, in 1882. The name was coined by another German anatomist, Heinrich von Waldeyer in 1888. It is New Latin from Ancient Greek κάρυον karyon, "kernel", "seed", or "nucleus", and τύπος typos, "general form") 

Note the following info on all notable persons mentioned on the Karyotype Wikipedia page: 

• Carl Wilhelm von Nägeli (26 or 27 March 1817 – 10 May 1891)
• Walther Flemming (21 April 1843 – 4 August 1905) 
• Heinrich Wilhelm Gottfried von Waldeyer-Hartz (6 October 1836 – 23 January 1921)  
• Cyril Dean Darlington (19 December 1903 – 26 March 1981)
• Michael James Denham White (20 August 1910 – 16 December 1983) 
• Theophilus Shickel Painter (August 22, 1889 – October 5, 1969) 
• Joe Hin Tjio (2 November 1919 – 27 November 2001)
• Albert Levan (8 March 1905 – 28 March 1998) 
•  Kurt Benirschke (May 26, 1924 – September 10, 2018)
• Theodor Heinrich Boveri (12 October 1862 – 15 October 1915) 
•  Murray Llewellyn Barr (June 20, 1908 – May 4, 1995) 
•  George Ledyard Stebbins Jr. (January 6, 1906 – January 19, 2000) 
• John Langdon Haydon Down (18 November 1828 – 7 October 1896)  

Interesting that the surname “Hart’s” should crop up... another addition to the “Timely” pattern cluster.  Several pattern clusters emerge, butt the one that stands out to me personally is the “October 5, 6, 7/Date Sequence” pattern cluster.  With the reason being that the surnames of the individuals involving those dates, generates an interesting cryptic phrase re: hart painter down.  Note the following info regarding a notable painter of a Hart (deer): 

Sir Edwin Henry Landseer  (7 March 1802 – 1 October 1873)

His date of birth and death jives in more ways than one!!  

Cyril died on Carl’s birthday (maybe, if the 26th and not the 27th)... and do note the “car” in Carl and Carmen above— a “Names Beginning with Car” pattern cluster.  Note this next excerpt from my previous post: 

• William Henry "Will" Wright (March 26, 1894 – June 19, 1962)  
• Lawrence L. "Larry" Morey (March 26, 1905 – May 8, 1971)   
• Marc Fraser Davis (March 30, 1913 – January 12, 2000) 
• Paula Winslowe (March 23, 1910 – March 6, 1996) 
• Donald George Novis (3 March 1906 – 23 July 1966)

A “March 26(x4)” pattern cluster.   And a “March 3, ..., 6, 7, 8, ..., 16, 23, ..., 26(x4), 27, 28, __, 30”Date Sequence” pattern cluster.  Keep in mind as well, that Will Wright’s date of death, June 19, is also the anniversary of this blog.  

Note this next excerpt from the Karyotype Wikipedia article:

Chromosome 2 is one of the twenty-three pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 2 is the second-largest human chromosome, spanning more than 242 million base pairs^[5] and representing almost eight percent of the total DNA in human cells

Note from the list found on the Chromosome 2 Wikipedia page:

• Hereditary nonpolyposis colorectal cancer
• Waardenburg syndrome

I chose to investigate two from the list, zeroing in on the first because of problems my step son has with colorectal polyps, and because one of his relatives had died of colorectal cancer... suggesting a genetic link.  And keep in mind, the comfort hearts referenced in my recent post are a small pewter heart that I designed are to raise funds for cancer research.  As for Waardenburg syndrome, the name stands out with it’s unusual “twin aa”!!

Applying the formula to the June 1 Wikipedia page, we arrive at: 

1999 – Christopher Cockerell, English engineer, invented the hovercraft (b. 1910)

2000 – Tito Puente, American drummer, composer, and producer (b. 1923)

• Sir Christopher Sydney Cockerell (4 June 1910 – 1 June 1999) 
• Ernest Anthony "Tito" Puente, Jr. (April 20, 1923 – June 1, 2000)

We now have a “June 1, 2, 3, 4/Date Sequence” pattern cluster in the works!! 

Going back now to the “October 1, ..., __, 5, 6, 7/Date Sequence” pattern cluster, lets bridge the October 4 gap using the formulas (http://pronoiasecrets.blogspot.ca/2017/01/formula.html) and taking into consideration the “one off” curve ball, to arrive at : 

• 1998 – S. Arasaratnam, Sri Lankan historian and academic (b. 1930)
• 1999 – Erik Brødreskift, Norwegian drummer (b. 1969)
• 1999 – Bernard Buffet, French painter and illustrator (b. 1928)
• 1999 – Art Farmer, American trumpet player and composer (b. 1928)
• 2000 – Yu Kuo-hwa, Chinese politician, 32nd Premier of the Republic of China (b. 1914)
• 2000 – Michael Smith, English-Canadian biochemist and geneticist, Nobel Prize laureate (b. 1932)
• 2001 – Blaise Alexander, American race car driver (b. 1976)
• 2001 – John Collins, American guitarist (b. 1913)
• 2001 – Ahron Soloveichik, Russian rabbi and scholar (b. 1917)

Let’s cut to the chase and select two who stands out the most after investigating each  further: 

Blaise Robert Alexander Jr. (March 26, 1976 – October 4, 2001) 

Ahron (Aaron) Soloveichik^](May 1, 1917 – October 4, 2001)

I, May, won AGAIN!!  (As per the cryptic “May won” in “May 1”).  

____________________

Extended research: 

Hereditary nonpolyposis colorectal cancer:

Henry T. Lynch, Professor of Medicine at Creighton University Medical Center, characterized the syndrome in 1966.

• Henry Thompson Lynch (January 4, 1928 – June 2, 2019)

 He is sometimes described as "the father of hereditary cancer detection and prevention"^[1] or the "father of cancer genetics",^[2] although Lynch himself said that title should go to the early 20th century pathologist Aldred Scott Warthin

 Aldred Scott Warthin (October 21, 1866 − May 23, 1931) was an American pathologist whose research laid the foundation for understanding the heritability of certain cancers. He has been described as "the father of cancer genetics.

•  Gregor Johann Mendel (20 July 1822^[3] – 6 January 1884) 

 Waardenburg syndrome:

Waardenburg syndrome is a group of rare genetic conditions characterised by at least some degree of congenital hearing loss and pigmentation deficiencies, which can include bright blue eyes (or one blue eye and one brown eye), a white forelock or patches of light skin. These basic features constitute type 2 of the condition; in type 1, there is also a wider gap between the inner corners of the eyes called telecanthus, or dystopia canthorum.^[1] In type 3, which is rare, the arms and hands are also malformed, with permanent finger contractures or fused fingers, while in type 4 the person also has Hirschsprung's disease

• Petrus Johannes Waardenburg (3 June 1886 – 23 September 1979)

Hirschsprung's disease (HD or HSCR) is a birth defect in which nerves are missing from parts of the intestine.^[1][3] The most prominent symptom is constipation.^[1] Other symptoms may include vomiting, abdominal pain, diarrhea and slow growth.

The first report of Hirschsprung's disease dates to 1691,^[40] when it was described by Dutch anatomist Frederik Ruysch.^[41] However, the disease is named after Harald Hirschsprung, the Danish physician who first described two infants who died of this disorder in 1888

• Frederik Ruysch (March 28, 1638 – February 22, 1731)
• Harald Hirschsprung (14 December 1830 – 11 April 1916)